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Vinayaka Missions had its inception in the year 1981 with the establishment of the Thirumuruga Kirupananda Variyar Thavathiru Sundara Swamigal (TKVTSS) Medical Educational and Charitable Trust. Not far from then, in 1982, the Founder-Chairman, Dr. A Shanmugasundaram instituted the Vinayaka Mission's College of Pharmacy in Salem, the pioneer institution of Vinayaka Missions. In the year 2001 the "Deemed to be University" status was conferred on Vinayaka Missions by The Ministry of Human Resources Development, Government of India, with the recommendations of the UGC Under Section 3 of the UGC Act, 1956 as an acknowledgement of its excellence, satisfaction of the highest level of academic standards and best infrastructural facilities provided to achieve preeminence in education and by virtue of this recognition Vinayaka Missions trascended to becoming Vinayaka Missions Research Foundation (VMRF) as the 48th University in India.

The conducive environment provided by the University helps every student to achieve excellence in their chosen field of specialization. Nearly 15,000 students are studying in the various constituent colleges, and every year approximately 2000 medical, dental, homoeopathy, paramedical, engineering and management professionals besides arts & science graduates graduate from the VMRF campuses successfully. The dynamic environment created by the Trust helps every student to develop his/ her rational, critical and creative powers, thereby enabling the fullest possible intellectual and personal growth.

Close to 5000 staff members including renowned Faculty, technical and other experts serve our student community to achieve excellence in education and to make studying at VMRF institutions an extremely pleasurable and rewarding experience. The success of VMRF lies in its highly qualified and experienced faculty who are competent and dedicated to provide excellent education. VMRF takes pride in being the only one of its kind in India that has established three medical colleges, one dental college, and two engineering colleges apart from other paramedical and homoeopathy colleges.